How does Cialis work in the body?
Cialis (tadalafil) is a drug primarily used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). Its mode of action in the body is both fascinating and effective. Here's a breakdown of how Cialis works:
1. The Role of PDE5:
When sexual stimulation occurs, nitric oxide is released into the penis. Nitric oxide activates an enzyme called guanylate cyclase, which increases levels of a molecule called cyclic guanosine monophosphate (cGMP).
cGMP causes the blood vessels in the penis to dilate, increasing blood flow and leading to an erection.
Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cGMP. When cGMP is broken down, the blood vessels return to their normal size, and the erection ends.
2. Cialis' Primary Mechanism:
Cialis functions as a PDE5 inhibitor. By blocking the action of the PDE5 enzyme, Cialis ensures that cGMP levels remain high for a longer period. This prolongs the dilation of blood vessels in the penis, allowing for a more extended and more consistent erection.
3. Duration of Effect:
One of the standout features of Cialis compared to other PDE5 inhibitors is its long half-life. This means it remains active in the body for an extended period. Depending on the dosage, Cialis can remain effective for up to 36 hours, which is why it's often referred to as the "weekend pill."
4. Cialis for BPH:
While the exact mechanism isn't entirely understood, Cialis has been shown to relieve the symptoms of BPH (enlarged prostate). It's believed that the drug relaxes the smooth muscles in the prostate and bladder, which can reduce symptoms like difficulty in starting the flow of urine, weak stream, and frequent urination.
Cialis doesn't induce erections directly. Sexual stimulation is still required to produce an erection even after taking the drug. This feature ensures that erections only occur when desired.
It's essential to note that the prolonged effect of Cialis can pose risks. An erection lasting more than 4 hours (priapism) can be dangerous and requires immediate medical attention.
Since Cialis affects blood vessel dilation, it can cause a drop in blood pressure. This is especially a concern if taken with nitrates (often prescribed for chest pain) or some blood pressure medications.
Cialis works by inhibiting the PDE5 enzyme, which regulates blood flow to the penis. This action helps men with ED maintain erections for longer durations. While the drug is effective, users should be aware of its potential interactions and side effects and always consult with a healthcare professional before starting or changing their treatment.